The Evidence for Progesterone for Miscarriage Prevention
Progesterone is an important hormone for the establishment and maintenance of pregnancy. Because of this important role, progesterone deficiency has been studied since the 1950s as a possible cause of some miscarriages. Many of the early studies done on progesterone were small and poor quality, making it difficult for doctors to make evidence-based recommendations for its use. However, more recently there have been two large, high-quality placebo controlled trials (the PROMISE trial and PRISM trial) that have shown encouraging results.
