Progesterone is an important hormone for the establishment and maintenance of pregnancy. Because of this important role, progesterone deficiency has been studied since the 1950s as a possible cause of some miscarriages. Many of the early studies done on progesterone were small and poor quality, making it difficult for doctors to make evidence-based recommendations for its use. However, more recently there have been two large, high-quality placebo controlled trials (the PROMISE trial and PRISM trial) that have shown encouraging results.
Women have many questions after a miscarriage. Unless the cause is discovered to be a genetic anomaly, infection, anatomical abnormality or advanced age, the answers are many times elusive. Our medical system does not fully investigate first trimester pregnancy loss unless it has happened two or sometimes three times. This can be devastating for people trying to conceive.