Description
Benefits:
- Magnesium citrate has been shown to have superior bioavailability to other forms of magnesium, increasing its clinical effectivenes
- Citrate-malate complexes increase mineral absorption, particularly among individuals with reduced gastric acid secretion
- Malic acid supplies an important substrate in the citric acid cycle, contributing to improved energy metabolism
- Conveniently dosed at 150 mg per capsule, allowing for easy therapeutic dosing
Ingredients:
| Each Vegetarian Capsule Contains: | |
| Magnesium (Citrate, Malate) | 150 mg |
| Sourced from 750 mg of magnesium complex yielding 150 mg elemental magnesium. | |
Non-Medicinal Ingredients:Vegetarian capsule (carbohydrate gum, purified water), microcrystalline cellulose, stearic acid, vegetable grade magnesium stearate (lubricant).
Recommended Adult Dose: 3 vegetarian capsules per day or as directed by a health care practitioner.
Warnings: Some people may experience diarrhea. Keep out of reach of children.
Allergens: Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Format: 90 Softgels
Contraindications: Magnesium supplementation is contraindicated in individuals with impaired kidney function, as well as those with heart blocks, such as atrioventricular or bifascicular blocks. Some people may experience diarrhea. Keep out of reach of children.
Drug Interactions: Magnesium may influence the absorption and/or actions of a number of medications, including calcium channel blockers, bisphosphonates, diuretics, digoxin, warfarin, and various antibiotics, though spacing their administration apart often minimizes any interaction. It has favourable effects on some medications that may require lower dosing, including albuterol, insulin, and other diabetes medications. Additionally, some medications significantly deplete magnesium levels, such as proton pump inhibitors, diuretics, antibiotics, and estrogens, suggesting a possible benefit of combined use.
Feature Summary: As the second most abundant intracellular cation and a cofactor for at least 600 enzymes, magnesium is a critical regulator of numerous cellular functions, ion channels, signalling pathways, enzymes, and metabolic pathways, including glycolysis, fatty acid oxidation, and DNA synthesis.1,2 Substantial epidemiological evidence indicates that a low magnesium intake is quite common and associated with diverse pathological conditions, particularly metabolic and inflammatory disorders and markers of inflammation, such as C-reactive protein and uric acid.3 Low intake of magnesium has also been associated with a greater risk for hypertension, osteoporosis, stroke, poor cognition, and cardiovascular disease.4–8 Magnesium is particularly important to cardiovascular function, influencing myocardial metabolism, calcium homeostasis, vascular tone, peripheral vascular resistance, and cardiac output.2 Supplementation with magnesium has also been shown to support cardiovascular health.9–12
Multiple studies indicate that magnesium citrate has greater bioavailability than other forms of magnesium.13,14 In addition to improving magnesium bioavailability, citrate itself is a mitochondrial substrate (as is malic acid), provides an alkaline load, and chelates dietary oxalates, reducing renal stone formation risk.15,16 Magnesium CitraMal provides fully reacted magnesium, indicating a lack of blended ingredients, and complete binding of magnesium with citrate and malate, associated with greater stability and bioavailability.
Related Documents
References
1. Long, S., & Romani, A.M. (2014). Role of cellular magnesium in human diseases. Austin J Nutr Food Sci, 2(10), 1051.
2. de Baaij, J.H.F., Hoenderop, J.G.J, & Bindels, R.J.M. (2015). Magnesium in man: Implications for health and disease. Physiol Rev, 95(1), 1-46.
3. Zhang, Y., & Qiu, H. (2018). Dietary magnesium intake and hyperuricemia among US adults. Nutrients, 10(3), 296.
4. Peeri, N.C., Egan, K.M., Chai, W., et al. (2021). Association of magnesium intake and vitamin D status with cognitive function in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Eur J Nutr, 60(1), 465-74.
5. Aydin, H., Deyneli, O., Yavuz, D., et al. (2010). Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women. Biol Trace Elem Res, 133(2), 136-43.
6. Zhao, B., Zeng, L., Zhao, J., et al. (2020). Association of magnesium intake with type 2 diabetes and total stroke: An updated systematic review and meta-analysis. BMJ Open, 10(3), e032240.
7. Fan, L., Zhu, X., Rosanoff, A., et al. (2021). Magnesium Depletion Score (MDS) predicts risk of systemic inflammation and cardiovascular mortality among US adults. J Nutr, 151(8), 2226-35.
8. Veronese, N., Stubbs, B., Solmi, M., et al. (2017). Dietary magnesium intake and fracture risk: Data from a large prospective study. Br J Nutr, 117(11), 1570-6.
9. Dibaba, D.T., Xun, P., Song, Y., et al. (2017). The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: A meta-analysis of randomized controlled trials. Am J Clin Nutr, 106(3), 921-9.
10. Zhang, X., Li, Y., Del Gobbo, L.C., et al. (2016). Effects of magnesium supplementation on blood pressure: A meta-analysis of randomized double-blind placebo-controlled trials. Hypertension, 68(2), 324-33.
11. Marques, B.C.A.A., Klein, M.R.S.T., da Cunha, M.R., et al. (2020). Effects of oral magnesium supplementation on vascular function: A systematic review and meta-analysis of randomized controlled trials. High Blood Press Cardiovasc Prev, 27(1), 19-28.
12. Joris, P.J., Plat, J., Bakker, S.J., et al. (2016). Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: Results of a randomized, double-blind, placebo-controlled intervention trial. Am J Clin Nutr, 103(5), 1260-6.
13. Werner, T., Kolisek, M., Vormann, J., et al. (2019). Assessment of bioavailability of Mg from Mg citrate and Mg oxide by measuring urinary excretion in Mg-saturated subjects. Magnes Res, 32(3), 63-71.
14. Walker, A.F., Marakis, G., Christie, S., et al. (2003). Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study. Magnes Res, 16(3), 183-91.
15. Zerwekh, J.E., Odvina, C.V., Wuermser, L.A., et al. (2007). Reduction of renal stone risk by potassium-magnesium citrate during 5 weeks of bed rest. J Urol, 177(6), 2179-84.
16. Phillips, R., Hanchanale, V.S., Myatt, A., et al. (2015). Citrate salts for preventing and treating calcium containing kidney stones in adults. Cochrane Database Syst Rev, 2015(10), CD010057.
17. Liamis, G., Hoorn, E.J., Florentin, M., et al. (2021). An overview of diagnosis and management of drug-induced hypomagnesemia. Pharmacol Res Perspect, 9(4), e00829.
Reviews
There are no reviews yet.