Description
Benefits:
- Provides fungal and bacterial proteases to hydrolyze difficult-to digest proline-containing peptides such as gluten and casein
- Provides broad-spectrum carbohydrate digestion with plant-based papain, bromelain, and fungal digestive enzymes
- High potency formulation allows for easy dosing, with nearly 300 mg enzyme blend delivered in each vegetarian capsule
- Completely suitable for vegetarians and vegans
Ingredients:
| Each Vegetarian Capsule Contains: | ||
| Enzyme blend | 267 mg | |
| Fungal protease*1 | 690 FCC SAP | 124.47 mg |
| Bacterial protease*2 | 75,000 FCC PC | 75 mg |
| Fungal protease*1 Providing 163 DPP-IV enzyme activity |
6,700 FCC HUT | 24.36 mg |
| Alpha-amylase*1 | 2,800 FCC DU | 18.67 mg |
| Bromelain*3 | 315,000 FCC PU | 9.55 mg |
| Papain*4 | 315,000 FCC PU | 7.5 mg |
| Cellulase*5 | 680 FCC CU | 3.78 mg |
| Hemicellulase*6 | 1,875 FCC HCU | 2.34 mg |
| (*1 Aspergillus flavus var. oryzae) (whole), (*2 Bacillus subtilis) (whole), (*3 Ananas comosus var. comosus) (pineapple stem), (*4 Carica papaya) (fruit), (*5 Trichoderma longibrachiatum) (whole), (*6 Aspergillus niger) (whole) | ||
| FCC: Food Chemical Codex; SAP: Spectrophotometric Acid Protease Unit; PC: Protease Unit; HUT: Hemoglobin Unit on the Tyrosine Basis; DU: Dextrinizing Unit; PU: Papain Unit; CU: Cellulase Unit; HCU: Hemicellulase Unit. | ||
Non-Medicinal Ingredients: Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant).
Recommended Adult Dose: 1 capsule 3 times per day with meals or as directed by a health care practitioner. Consult a health care practitioner for prolonged use.
Warnings: Consult a health care practitioner prior to use if you have diabetes or a gastrointestinal lesion/ulcer, are taking anticoagulant/blood thinner agents, anti-inflammatory agents, or antibiotics, are having surgery, are pregnant or breastfeeding, or have an allergy to latex or fruits (e.g., avocado, banana, chestnut, passion fruit, fig, melon, mango, kiwi, pineapple, peach, and tomato). Stop use if hypersensitivity/allergy, nausea, vomiting, or diarrhea occurs. Keep out of reach of children.
Allergens: Contains no artificial colours, preservatives, or sweeteners; no sugar, wheat, gluten, yeast, egg, fish, shellfish, salt, tree nuts, or GMOs. Suitable for vegetarians. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Format: 60 Capsules
Contraindications: Consult a health care practitioner prior to use if you have diabetes, a gastrointestinal lesion, ulcer, are taking an anticoagulant, blood thinner, anti-inflammatory, antibiotic, or are having surgery, are pregnant or breastfeeding, or have allergy to latex or fruits (avocado, banana, chestnut, passion fruit, fig, melon, mango, kiwi, pineapple, peach, tomato).
Drug Interactions:No known drug interactions.
Feature Summary: Digest-ProGD HP is a high-potency proprietary enzyme blend for comprehensive carbohydrate digestion. It provides fungal proteases derived from Aspergillus oryzae, bacterial protease from Bacillus subtilis, and comprehensive carbohydrate digestive support from papain, bromelain, and fungal digestive enzymes. Aspergillus oryzae extracts are rich in prolyl endopeptidases and dipeptidyl peptidase IV (DPP-IV) – a multifunctional serine protease that targets proline-containing peptides, such as those found in both gliadin and casein, both proteolytically resistant proteins.
Indeed, protease activity from Aspergillus oryzae targets the proline-rich 33-mer of gliadin, perhaps the most immunotoxic peptide derived from gliadin. The antigenic and immunomodulatory proline-rich proteins found in gluten are thought to trigger an inflammatory response in patients with either celiac disease or gluten sensitivity, often because of accidental gluten exposure, even for people on a gluten-free diet. Supplementation with protease from Aspergillus oryzae has also been linked to a bifidogenic effect in animals, suggesting a potential probiotic effect, as well as an increase in gut-protective amino acids.
In addition to fungal and bacterial proteases, Digest-ProGD HP provides alpha-amylase, cellulose, and hemicellulose activity for comprehensive carbohydrate digestion support.
References
- Mulvihill EE, Drucker DJ. Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors. Endocr Rev. 2014 Dec;35(6):992-1019. doi: 10.1210/er.2014-1035.
- Nongonierma AB, FitzGerald RJ. Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chem. 2014 Feb 15;145:845-52. doi: 10.1016/j.foodchem.2013.08.097.
- Lambeir AM, Durinx C, Scharpé S, De Meester I. Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit Rev Clin Lab Sci. 2003 Jun;40(3):209-94.
- Eugster PJ, Salamin K, Grouzmann E, et al. Production and characterization of two major Aspergillus oryzae secreted prolyl endopeptidases able to efficiently digest proline-rich peptides of gliadin. Microbiology. 2015 Dec;161(12):2277-88.
- Cerf-Bensussan N, Matysiak-Budnik T, Cellier C, Heyman M. Oral proteases: a new approach to managing coeliac disease. Gut. 2007 Feb;56(2):157-60. Epub 2006 Sep 1.
- Yang Y, Iwamoto A, Kumrungsee T, et al. Consumption of an acid protease derived from Aspergillus oryzae causes bifidogenic effect in rats. Nutr Res. 2017 Aug;44:60-66.
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